SFTPC

Controlled terms (disease, cell states), underlying studies and statistical methods are defined here.

Filter the cells
No filter. Every cell of the atlas is included.

Expression by cell type

Mean expression per group, sorted highest first. Circle area is the fraction of cells with non-zero expression.

low high mean expression

Cell states and expression on the UMAP

The same embedding twice. Left: every cell state in its scALABLE colour, labelled at its own centre. Right: this feature's relative expression, on the scALABLE gradient for its modality.

Cell states

Differential expression in disease

Log fold change per cell type and disease comparison. Red is higher in disease, blue is lower. A bordered square passes FDR < 0.05.

down no change up FDR < 0.05 comparison never run
0 0.05

Variation between samples

Each point is one sample, averaged over its cells. The box shows the quartile range of individual cells.

Developmental expression

Expression across developmental stages. Human fetal lung spans Carnegie stage 16 to 22 weeks post-fertilisation; mouse lung spans embryonic day 16 to postnatal day 28. Neither atlas contains disease samples.

Interaction partners

Protein-protein and protein-DNA interactions from BioGRID and DoRothEA. Partner colour shows its strongest differential in the adult atlas. Click a partner to open its page.

partner down in disease partner up no significant change

Data sources

Human postnatal, Gene expression — 228,827 cells, 36,601 genes, carrying the disease axis.
Human postnatal, Antibody (imputed) — 228,827 cells, 56 antibodies, carrying the disease axis.
Human postnatal, Lipid (imputed) — 228,827 cells, 202 lipid species, carrying the disease axis.
Human postnatal, Gene regulation (imputed) — 228,827 cells, 284 transcription factors, carrying the disease axis.
Human fetal lung atlas (development) — 71,752 cells, 26,286 genes, carrying the development axis.
LungMAP mouse lung CellRef (development) — 71,439 cells, 26,727 genes, carrying the development axis.
Expression is the normalized log value each atlas declares, and every value axis names its base. Differential results, marker statistics and interaction records are the ones computed into those atlases; this page reads them and does not recompute them. Interactions come from BioGRID and DoRothEA and are literature records rather than measurements from these cells.