Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease

Yuening Zhang¹, Huanhuan Wei¹, Jessica Nouws¹, Wenhao Jiang¹, Reginald M Brewster¹, Jenny P Nguyen¹, SiRu Liang¹, Samuel M Pass¹, Weiwei Wang, Florine Collin, Angela Taravella Oill², Sang-Hun Kim¹, Saul S Siller¹, Jinjiang Liu, Amy Y Zhao¹, Phillip Hansbro, Charles Dela Cruz, Clemente Britto¹, Jose Gomez¹, Suzanne M Cloonan, Erica L Herzog¹, TuKiet T Lam², Nicholas E. Banovich², Micha Sam B Raredon¹, Xuchen Zhang¹, Stefano Mangiola³, Robert J Homer¹, Naftali Kaminski¹, John McDonough, Francesca Polverino⁴, Xiting Yan¹, Maor Sauler¹

¹Yale School of Medicine, ²Translational Genomics Research Institute, ³University of Melbourne, ⁴Baylor College of Medicine, ^*Corresponding author

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Description To investigate COPD heterogeneity, we profiled lung tissue by single-nucleus RNA sequencing from 141 study participants (1,516,727 nuclei) and identified shifts in cell composition and emergent cell states that correlated with lung function, emphysema and composite symptom scores. Epithelial regenerative states peaked in early COPD and declined thereafter, whereas inflamed nonimmune cells and profibrotic/remodeling states, together with select immune populations, expanded with disease progression. Clustering study participants by the proportion of pathologic cells coupled with spatial transcriptomics identified distinct patterns of cellular co-occurrence within spatially localized niches. Proteomic analyses identified plasma biomarkers of cell states and their impact on the extracellular matrix. Mediation and cell communication analyses revealed cell-autonomous and intercellular communication networks associated with disease. The data released here are metacells rather than individual nuclei: each metacell sums the counts of cells from two metadata-matched donors, and every metacell belongs to one of 178 meta-samples formed from 2 or 3 such donors. Clinical values are reported only as aggregates over those donor groups, so no released record corresponds to a single participant.

Dataset ID LMEX0000009416

Assay Type Single-nucleus RNA-seq

Organism Human

Stages Adult | 65+ years

Cell Count 123076

Technology 10x Genomics Chromium Single Cell Gene Expression

External databases GEO: GSE310058

File	Description	Size
COPD_metacells.metasample.h5ad	Released metacell expression matrix for the v8 viewers, HDF5 AnnData. 83,416 metacells x 36,212 genes over the 50 HLCA cell states in 6 superclasses, 178 meta-samples and 18 pools. X holds the summed raw integer counts of each metacell's member cells; layers['lognorm'] holds log1p of counts per ten thousand. obs carries the cell state, the meta-sample, the pool and stratum, the COPD and cancer status, and the clinical covariates that are constant inside a meta-sample; obsm carries three embeddings, X_umap, X_scanpy and X_umap_approx. Each metacell pools 20 source cells, 10 at the smallest, drawn from the meta-sample's 3 donors, or 2 where the cohort admits only two, and no source cell is used twice; 1,662,470 source cells are represented. This is the object the site's Morpheus, chart and scALABLE viewers read.	3004.5 MB
COPD_metasample_metadata.tsv	Per-meta-sample metadata derived from the release object above: one row for each of the 178 meta-samples, 24 columns. It carries the LungMAP sample record (name, age, sex, race, health status, age range, taxon) and the derived fields: meta-sample, pool, stratum, metacells contributed, donors in the meta-sample, cells per metacell, COPD and cancer status, age, BMI, FEV1 percent predicted, FEV1/FVC ratio, DLCO percent predicted, smoking pack years and GOLD stage. The n_metacells column sums to 83,416, the metacell total of the object above.	43.4 KB

LungMAP ID	Alt ID	Species	Sex	Race	Age	Age Group	Health Status
LMSPCOPD0000001	COPD-cancer-F-m1	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000010	COPD-cancer-F-m10	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000011	COPD-cancer-F-m11	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000012	COPD-cancer-F-m12	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000013	COPD-cancer-F-m13	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000014	COPD-cancer-F-m14	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000015	COPD-cancer-F-m15	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000016	COPD-cancer-F-m16	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000017	COPD-cancer-F-m17	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000018	COPD-cancer-F-m18	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000019	COPD-cancer-F-m19	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000002	COPD-cancer-F-m2	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000020	COPD-cancer-F-m20	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000021	COPD-cancer-F-m21	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000003	COPD-cancer-F-m3	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000004	COPD-cancer-F-m4	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000005	COPD-cancer-F-m5	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000006	COPD-cancer-F-m6	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000007	COPD-cancer-F-m7	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000008	COPD-cancer-F-m8	Homo sapiens	Female	White	67.5 years	65+ years	COPD
LMSPCOPD0000009	COPD-cancer-F-m9	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000022	COPD-cancer-M-m1	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000031	COPD-cancer-M-m10	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000032	COPD-cancer-M-m11	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000033	COPD-cancer-M-m12	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000034	COPD-cancer-M-m13	Homo sapiens	Male	White	76.4 years	65+ years	COPD
LMSPCOPD0000035	COPD-cancer-M-m14	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000036	COPD-cancer-M-m15	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000037	COPD-cancer-M-m16	Homo sapiens	Male	White	76.4 years	65+ years	COPD
LMSPCOPD0000038	COPD-cancer-M-m17	Homo sapiens	Male	White	76.4 years	65+ years	COPD
LMSPCOPD0000023	COPD-cancer-M-m2	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000024	COPD-cancer-M-m3	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000025	COPD-cancer-M-m4	Homo sapiens	Male	White	76.4 years	65+ years	COPD
LMSPCOPD0000026	COPD-cancer-M-m5	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000027	COPD-cancer-M-m6	Homo sapiens	Male	White	76.4 years	65+ years	COPD
LMSPCOPD0000028	COPD-cancer-M-m7	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000029	COPD-cancer-M-m8	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000030	COPD-cancer-M-m9	Homo sapiens	Male	White	63.0 years	Adult	COPD
LMSPCOPD0000039	COPD-nocancer-F-m1	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000048	COPD-nocancer-F-m10	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000049	COPD-nocancer-F-m11	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000050	COPD-nocancer-F-m12	Homo sapiens	Female	White	59.8 years	Adult	COPD
LMSPCOPD0000051	COPD-nocancer-F-m13	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000052	COPD-nocancer-F-m14	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000053	COPD-nocancer-F-m15	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000054	COPD-nocancer-F-m16	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000055	COPD-nocancer-F-m17	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000056	COPD-nocancer-F-m18	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000057	COPD-nocancer-F-m19	Homo sapiens	Female	White	59.8 years	Adult	COPD
LMSPCOPD0000040	COPD-nocancer-F-m2	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000058	COPD-nocancer-F-m20	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000059	COPD-nocancer-F-m21	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000060	COPD-nocancer-F-m22	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000061	COPD-nocancer-F-m23	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000062	COPD-nocancer-F-m24	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000063	COPD-nocancer-F-m25	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000064	COPD-nocancer-F-m26	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000065	COPD-nocancer-F-m27	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000066	COPD-nocancer-F-m28	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000067	COPD-nocancer-F-m29	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000041	COPD-nocancer-F-m3	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000068	COPD-nocancer-F-m30	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000069	COPD-nocancer-F-m31	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000070	COPD-nocancer-F-m32	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000071	COPD-nocancer-F-m33	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000072	COPD-nocancer-F-m34	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000073	COPD-nocancer-F-m35	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000074	COPD-nocancer-F-m36	Homo sapiens	Female	White	59.8 years	Adult	COPD
LMSPCOPD0000075	COPD-nocancer-F-m37	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000076	COPD-nocancer-F-m38	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000077	COPD-nocancer-F-m39	Homo sapiens	Female	White	59.8 years	Adult	COPD
LMSPCOPD0000042	COPD-nocancer-F-m4	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000078	COPD-nocancer-F-m40	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000079	COPD-nocancer-F-m41	Homo sapiens	Female	White	59.8 years	Adult	COPD
LMSPCOPD0000080	COPD-nocancer-F-m42	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000081	COPD-nocancer-F-m43	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000082	COPD-nocancer-F-m44	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000083	COPD-nocancer-F-m45	Homo sapiens	Female	White	59.8 years	Adult	COPD
LMSPCOPD0000084	COPD-nocancer-F-m46	Homo sapiens	Female	White	59.6 years	Adult	COPD
LMSPCOPD0000085	COPD-nocancer-F-m47	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000086	COPD-nocancer-F-m48	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000087	COPD-nocancer-F-m49	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000043	COPD-nocancer-F-m5	Homo sapiens	Female	White	60.5 years	Adult	COPD
LMSPCOPD0000088	COPD-nocancer-F-m50	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000044	COPD-nocancer-F-m6	Homo sapiens	Female	White	61.2 years	Adult	COPD
LMSPCOPD0000045	COPD-nocancer-F-m7	Homo sapiens	Female	White	59.8 years	Adult	COPD
LMSPCOPD0000046	COPD-nocancer-F-m8	Homo sapiens	Female	White	67.1 years	65+ years	COPD
LMSPCOPD0000047	COPD-nocancer-F-m9	Homo sapiens	Female	White	59.8 years	Adult	COPD
LMSPCOPD0000089	COPD-nocancer-M-m1	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000098	COPD-nocancer-M-m10	Homo sapiens	Male	White	60.8 years	Adult	COPD
LMSPCOPD0000099	COPD-nocancer-M-m11	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000100	COPD-nocancer-M-m12	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000101	COPD-nocancer-M-m13	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000102	COPD-nocancer-M-m14	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000103	COPD-nocancer-M-m15	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000104	COPD-nocancer-M-m16	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000105	COPD-nocancer-M-m17	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000106	COPD-nocancer-M-m18	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000107	COPD-nocancer-M-m19	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000090	COPD-nocancer-M-m2	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000108	COPD-nocancer-M-m20	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000109	COPD-nocancer-M-m21	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000110	COPD-nocancer-M-m22	Homo sapiens	Male	White	60.1 years	Adult	COPD
LMSPCOPD0000111	COPD-nocancer-M-m23	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000112	COPD-nocancer-M-m24	Homo sapiens	Male	White	60.8 years	Adult	COPD
LMSPCOPD0000113	COPD-nocancer-M-m25	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000114	COPD-nocancer-M-m26	Homo sapiens	Male	White	60.8 years	Adult	COPD
LMSPCOPD0000115	COPD-nocancer-M-m27	Homo sapiens	Male	White	60.1 years	Adult	COPD
LMSPCOPD0000116	COPD-nocancer-M-m28	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000117	COPD-nocancer-M-m29	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000091	COPD-nocancer-M-m3	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000118	COPD-nocancer-M-m30	Homo sapiens	Male	White	60.1 years	Adult	COPD
LMSPCOPD0000119	COPD-nocancer-M-m31	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000120	COPD-nocancer-M-m32	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000121	COPD-nocancer-M-m33	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000122	COPD-nocancer-M-m34	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000123	COPD-nocancer-M-m35	Homo sapiens	Male	White	60.1 years	Adult	COPD
LMSPCOPD0000124	COPD-nocancer-M-m36	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000125	COPD-nocancer-M-m37	Homo sapiens	Male	White	60.1 years	Adult	COPD
LMSPCOPD0000126	COPD-nocancer-M-m38	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000127	COPD-nocancer-M-m39	Homo sapiens	Male	White	60.1 years	Adult	COPD
LMSPCOPD0000092	COPD-nocancer-M-m4	Homo sapiens	Male	White	60.8 years	Adult	COPD
LMSPCOPD0000128	COPD-nocancer-M-m40	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000129	COPD-nocancer-M-m41	Homo sapiens	Male	White	60.8 years	Adult	COPD
LMSPCOPD0000130	COPD-nocancer-M-m42	Homo sapiens	Male	White	60.8 years	Adult	COPD
LMSPCOPD0000131	COPD-nocancer-M-m43	Homo sapiens	Male	White	64.8 years	Adult	COPD
LMSPCOPD0000132	COPD-nocancer-M-m44	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000133	COPD-nocancer-M-m45	Homo sapiens	Male	White	60.8 years	Adult	COPD
LMSPCOPD0000134	COPD-nocancer-M-m46	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000135	COPD-nocancer-M-m47	Homo sapiens	Male	White	60.8 years	Adult	COPD
LMSPCOPD0000136	COPD-nocancer-M-m48	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000137	COPD-nocancer-M-m49	Homo sapiens	Male	White	60.1 years	Adult	COPD
LMSPCOPD0000093	COPD-nocancer-M-m5	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000138	COPD-nocancer-M-m50	Homo sapiens	Male	White	60.1 years	Adult	COPD
LMSPCOPD0000139	COPD-nocancer-M-m51	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000140	COPD-nocancer-M-m52	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000141	COPD-nocancer-M-m53	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000094	COPD-nocancer-M-m6	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000095	COPD-nocancer-M-m7	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000096	COPD-nocancer-M-m8	Homo sapiens	Male	White	71.4 years	65+ years	COPD
LMSPCOPD0000097	COPD-nocancer-M-m9	Homo sapiens	Male	White	52.4 years	Adult	COPD
LMSPCOPD0000142	nonCOPD-cancer-F-m1	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000151	nonCOPD-cancer-F-m10	Homo sapiens	Female	White	66.0 years	65+ years
LMSPCOPD0000152	nonCOPD-cancer-F-m11	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000153	nonCOPD-cancer-F-m12	Homo sapiens	Female	White	66.0 years	65+ years
LMSPCOPD0000154	nonCOPD-cancer-F-m13	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000155	nonCOPD-cancer-F-m14	Homo sapiens	Female	White	66.0 years	65+ years
LMSPCOPD0000156	nonCOPD-cancer-F-m15	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000157	nonCOPD-cancer-F-m16	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000158	nonCOPD-cancer-F-m17	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000159	nonCOPD-cancer-F-m18	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000160	nonCOPD-cancer-F-m19	Homo sapiens	Female	White	66.0 years	65+ years
LMSPCOPD0000143	nonCOPD-cancer-F-m2	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000161	nonCOPD-cancer-F-m20	Homo sapiens	Female	White	66.0 years	65+ years
LMSPCOPD0000162	nonCOPD-cancer-F-m21	Homo sapiens	Female	White	66.0 years	65+ years
LMSPCOPD0000163	nonCOPD-cancer-F-m22	Homo sapiens	Female	White	66.0 years	65+ years
LMSPCOPD0000164	nonCOPD-cancer-F-m23	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000165	nonCOPD-cancer-F-m24	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000144	nonCOPD-cancer-F-m3	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000145	nonCOPD-cancer-F-m4	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000146	nonCOPD-cancer-F-m5	Homo sapiens	Female	White	66.0 years	65+ years
LMSPCOPD0000147	nonCOPD-cancer-F-m6	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000148	nonCOPD-cancer-F-m7	Homo sapiens	Female	White	66.0 years	65+ years
LMSPCOPD0000149	nonCOPD-cancer-F-m8	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000150	nonCOPD-cancer-F-m9	Homo sapiens	Female	White	51.0 years	Adult
LMSPCOPD0000166	nonCOPD-cancer-M-m1	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000175	nonCOPD-cancer-M-m10	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000176	nonCOPD-cancer-M-m11	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000177	nonCOPD-cancer-M-m12	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000167	nonCOPD-cancer-M-m2	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000168	nonCOPD-cancer-M-m3	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000169	nonCOPD-cancer-M-m4	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000170	nonCOPD-cancer-M-m5	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000171	nonCOPD-cancer-M-m6	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000172	nonCOPD-cancer-M-m7	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000173	nonCOPD-cancer-M-m8	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000174	nonCOPD-cancer-M-m9	Homo sapiens	Male	White	69.9 years	65+ years
LMSPCOPD0000178	nonCOPD-nocancer-M-m1	Homo sapiens	Male	White	59.5 years	Adult