Single-nucleus ATAC-seq analysis of lymphangioleiomyomatosis (LAM)
1University of Cincinnati College of Medicine, 2Cincinnati Children's Hospital Medical Center, *Corresponding author
Description
Single-nucleus ATAC-seq of lymphangioleiomyomatosis (LAM) lungs to construct gene regulatory network controlling the transcriptional program of LAM cells. In vivo and in vitro LAM models were used to identify molecular mechanisms mediating LAM cell pathogenesis. Integrative single cell omics analyses identified the activation of uterine specific HOX-PBX transcriptional programs in pulmonary LAMCORE cells.
Dataset ID
LMEX0000004413
Assay Type
Single-nucleus ATAC-seq
Organism
Human
Stages
Adult | 65+ years
Sample Count
10050
Sample Prep
Lmdata:sample_type_single_nucleus
Technology
10x Genomics Chromium Single Cell Multiome ATAC + Gene Expression
Reference
Olatoke et al. (2023)
External databases
GEO: GSE217106
| LungMAP ID | Alt ID | Species | Sex | Race | Age | Age Group | GA at Birth | CGA | Weight | Weight Percentile | Cause of Death | Type of Death |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LMSP0000001588 | D213 | Homo sapiens | Female | White | 23 months | Child | 40 weeks, 3 days | 143.29 weeks | 13.7 kg | 92 | Lung Disease - Viral Pneumonia | DBD (after brain death) |
| LMSP0000001586 | LAM3 | Homo sapiens | Female | 65 years | 65+ years | |||||||
| LMSP0000001587 | LAM32 | Homo sapiens | Female | 55 years | Adult |
3 of this study's 3 samples were also assayed by 1 other LungMAP studies, across 1 modality. Click any node to list those studies.