Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease
Yuening Zhang1, Huanhuan Wei1, Jessica Nouws1, Wenhao Jiang1, Reginald M Brewster1, Jenny P Nguyen1, SiRu Liang1, Samuel M Pass1, Weiwei Wang, Florine Collin, Angela Taravella Oill2, Sang-Hun Kim1, Saul S Siller1, Jinjiang Liu, Amy Y Zhao1, Phillip Hansbro, Charles Dela Cruz, Clemente Britto1, Jose Gomez1, Suzanne M Cloonan, Erica L Herzog1, TuKiet T Lam2, Nicholas E. Banovich2, Micha Sam B Raredon1, Xuchen Zhang1, Stefano Mangiola3, Robert J Homer1, Naftali Kaminski1, John McDonough, Francesca Polverino4, Xiting Yan1, Maor Sauler1
1Yale School of Medicine, 2Translational Genomics Research Institute, 3University of Melbourne, 4Baylor College of Medicine, *Corresponding author
AF FEV1 high vs low DEGsAF FEV1/FVC high vs low DEGsAF GOLD IV vs GOLD I-II DEGsAF explant vs lobectomy DEGsAF male vs female DEGsAF marker genesAM current smoker vs never DEGsAM former smoker vs never DEGsAM male vs female DEGsAM marker genesAM-lipid COPD vs non-COPD DEGsAM-lipid DLCO high vs low DEGsAM-lipid FEV1 high vs low DEGsAM-lipid current smoker vs never DEGsAM-lipid explant vs lobectomy DEGsAM-lipid former smoker vs never DEGsAM-lipid male vs female DEGsAM-lipid marker genesAM-lipid weight high vs low DEGsAM-prolif COPD vs non-COPD DEGsAM-prolif DLCO high vs low DEGsAM-prolif FEV1 high vs low DEGsAM-prolif male vs female DEGsAM-prolif marker genesAM-prolif weight high vs low DEGsASMC DLCO high vs low DEGsASMC explant vs lobectomy DEGsASMC former smoker vs never DEGsASMC male vs female DEGsASMC marker genesASMC weight high vs low DEGsAT1 COPD vs non-COPD DEGsAT1 DLCO high vs low DEGsAT1 FEV1 high vs low DEGsAT1 FEV1/FVC high vs low DEGsAT1 FVC high vs low DEGsAT1 GOLD IV vs GOLD I-II DEGsAT1 cancer vs no cancer DEGsAT1 explant vs lobectomy DEGsAT1 former smoker vs never DEGsAT1 male vs female DEGsAT1 marker genesAT1 weight high vs low DEGsAT2 COPD vs non-COPD DEGsAT2 DLCO high vs low DEGsAT2 FEV1 high vs low DEGsAT2 FEV1/FVC high vs low DEGsAT2 FVC high vs low DEGsAT2 GOLD IV vs GOLD I-II DEGsAT2 cancer vs no cancer DEGsAT2 current smoker vs never DEGsAT2 explant vs lobectomy DEGsAT2 former smoker vs never DEGsAT2 male vs female DEGsAT2 marker genesAT2 pack years high vs low DEGsAT2 weight high vs low DEGsAT2-AT1 int. DLCO high vs low DEGsAT2-AT1 int. FEV1/FVC high vs low DEGsAT2-AT1 int. FVC high vs low DEGsAT2-AT1 int. GOLD IV vs GOLD I-II DEGsAT2-AT1 int. cancer vs no cancer DEGsAT2-AT1 int. explant vs lobectomy DEGsAT2-AT1 int. male vs female DEGsAT2-AT1 int. marker genesAT2-AT1 int. weight high vs low DEGsAT2-prolif DLCO high vs low DEGsAT2-prolif male vs female DEGsAT2-prolif marker genesAberrant basal DLCO high vs low DEGsAberrant basal FEV1 high vs low DEGsAberrant basal FEV1/FVC high vs low DEGsAberrant basal FVC high vs low DEGsAberrant basal GOLD IV vs GOLD I-II DEGsAberrant basal cancer vs no cancer DEGsAberrant basal explant vs lobectomy DEGsAberrant basal male vs female DEGsAberrant basal marker genesAberrant basal weight high vs low DEGsAdvFB male vs female DEGsAdvFB weight high vs low DEGsB DLCO high vs low DEGsB FEV1/FVC high vs low DEGsB GOLD IV vs GOLD I-II DEGsB explant vs lobectomy DEGsB former smoker vs never DEGsB male vs female DEGsB marker genesB pack years high vs low DEGsB weight high vs low DEGsB-lineage COPD vs non-COPD DEGsB-lineage DLCO high vs low DEGsB-lineage GOLD IV vs GOLD I-II DEGsB-lineage male vs female DEGsBasal COPD vs non-COPD DEGsBasal DLCO high vs low DEGsBasal FEV1/FVC high vs low DEGsBasal GOLD IV vs GOLD I-II DEGsBasal explant vs lobectomy DEGsBasal male vs female DEGsBasal marker genesBasal weight high vs low DEGsCAP1 cancer vs no cancer DEGsCAP1 male vs female DEGsCAP1 marker genesCAP1 weight high vs low DEGsCAP1-int COPD vs non-COPD DEGsCAP1-int DLCO high vs low DEGsCAP1-int FEV1 high vs low DEGsCAP1-int FEV1/FVC high vs low DEGsCAP1-int cancer vs no cancer DEGsCAP1-int current smoker vs never DEGsCAP1-int explant vs lobectomy DEGsCAP1-int former smoker vs never DEGsCAP1-int male vs female DEGsCAP1-int marker genesCAP1-int weight high vs low DEGsCD4 T COPD vs non-COPD DEGsCD4 T FVC high vs low DEGsCD4 T cancer vs no cancer DEGsCD4 T explant vs lobectomy DEGsCD4 T male vs female DEGsCD4 T weight high vs low DEGsCD8 T DLCO high vs low DEGsCD8 T GOLD IV vs GOLD I-II DEGsCD8 T male vs female DEGsCOPD cell-state marker genesCiliated-Bronch DLCO high vs low DEGsCiliated-Bronch FEV1 high vs low DEGsCiliated-Bronch current smoker vs never DEGsCiliated-Bronch explant vs lobectomy DEGsCiliated-Bronch former smoker vs never DEGsCiliated-Bronch male vs female DEGsCiliated-Bronch marker genesCiliated-TB pack years high vs low DEGsCiliated-axon COPD vs non-COPD DEGsCiliated-axon DLCO high vs low DEGsCiliated-axon FEV1 high vs low DEGsCiliated-axon FEV1/FVC high vs low DEGsCiliated-axon cancer vs no cancer DEGsCiliated-axon current smoker vs never DEGsCiliated-axon explant vs lobectomy DEGsCiliated-axon former smoker vs never DEGsCiliated-axon male vs female DEGsCiliated-axon marker genesCiliated-axon weight high vs low DEGsClub-Bronch FVC high vs low DEGsClub-Bronch GOLD IV vs GOLD I-II DEGsClub-TB COPD vs non-COPD DEGsClub-TB DLCO high vs low DEGsClub-TB explant vs lobectomy DEGsClub-TB former smoker vs never DEGsClub-TB male vs female DEGsClub-TB marker genesClub-TB weight high vs low DEGsDeuterosomal COPD vs non-COPD DEGsErythrocyte marker genesGoblet DLCO high vs low DEGsGoblet FEV1/FVC high vs low DEGsGoblet cancer vs no cancer DEGsGoblet current smoker vs never DEGsGoblet explant vs lobectomy DEGsGoblet former smoker vs never DEGsGoblet male vs female DEGsGoblet marker genesGoblet weight high vs low DEGsHSC DLCO high vs low DEGsHSC male vs female DEGsILC1 GOLD IV vs GOLD I-II DEGsILC1 male vs female DEGsILC1 weight high vs low DEGsIM DLCO high vs low DEGsIM FEV1/FVC high vs low DEGsIM cancer vs no cancer DEGsIM explant vs lobectomy DEGsIM male vs female DEGsIM marker genesIM weight high vs low DEGsIntFB COPD vs non-COPD DEGsIntFB DLCO high vs low DEGsIntFB FEV1 high vs low DEGsIntFB FEV1/FVC high vs low DEGsIntFB FVC high vs low DEGsIntFB GOLD IV vs GOLD I-II DEGsIntFB cancer vs no cancer DEGsIntFB current smoker vs never DEGsIntFB explant vs lobectomy DEGsIntFB former smoker vs never DEGsIntFB male vs female DEGsIntFB marker genesIntFB weight high vs low DEGsIonocyte DLCO high vs low DEGsIonocyte explant vs lobectomy DEGsIonocyte male vs female DEGsLEC-cycling COPD vs non-COPD DEGsLEC-cycling DLCO high vs low DEGsLEC-cycling FEV1 high vs low DEGsLEC-cycling FEV1/FVC high vs low DEGsLEC-cycling FVC high vs low DEGsLEC-cycling GOLD IV vs GOLD I-II DEGsLEC-cycling cancer vs no cancer DEGsLEC-cycling explant vs lobectomy DEGsLEC-cycling former smoker vs never DEGsLEC-cycling male vs female DEGsLEC-cycling marker genesLEC-cycling weight high vs low DEGsLangerhans DLCO high vs low DEGsLangerhans explant vs lobectomy DEGsLangerhans male vs female DEGsLangerhans marker genesLangerhans pack years high vs low DEGsLangerhans weight high vs low DEGsLipoFB1 DLCO high vs low DEGsLipoFB1 cancer vs no cancer DEGsLipoFB1 explant vs lobectomy DEGsLipoFB1 male vs female DEGsLipoFB1 marker genesLipoFB1 pack years high vs low DEGsLipoFB1 weight high vs low DEGsMT+ AM FEV1 high vs low DEGsMT+ AM FEV1/FVC high vs low DEGsMT+ AM GOLD IV vs GOLD I-II DEGsMT+ AM current smoker vs never DEGsMT+ AM former smoker vs never DEGsMast COPD vs non-COPD DEGsMast DLCO high vs low DEGsMast FEV1 high vs low DEGsMast cancer vs no cancer DEGsMast former smoker vs never DEGsMast male vs female DEGsMast marker genesMegakaryocyte COPD vs non-COPD DEGsMegakaryocyte DLCO high vs low DEGsMegakaryocyte cancer vs no cancer DEGsMegakaryocyte male vs female DEGsMesothelial COPD vs non-COPD DEGsMesothelial DLCO high vs low DEGsMesothelial FEV1 high vs low DEGsMesothelial FVC high vs low DEGsMesothelial GOLD IV vs GOLD I-II DEGsMesothelial explant vs lobectomy DEGsMesothelial former smoker vs never DEGsMesothelial male vs female DEGsMesothelial marker genesMesothelial weight high vs low DEGsNK COPD vs non-COPD DEGsNK DLCO high vs low DEGsNK FEV1/FVC high vs low DEGsNK cancer vs no cancer DEGsNK explant vs lobectomy DEGsNK male vs female DEGsNK marker genesNeutrophil DLCO high vs low DEGsNeutrophil FEV1 high vs low DEGsNeutrophil FVC high vs low DEGsNeutrophil GOLD IV vs GOLD I-II DEGsNeutrophil explant vs lobectomy DEGsNeutrophil male vs female DEGsPAEC COPD vs non-COPD DEGsPAEC DLCO high vs low DEGsPAEC FEV1 high vs low DEGsPAEC FEV1/FVC high vs low DEGsPAEC FVC high vs low DEGsPAEC cancer vs no cancer DEGsPAEC explant vs lobectomy DEGsPAEC former smoker vs never DEGsPAEC male vs female DEGsPAEC marker genesPAEC pack years high vs low DEGsPAEC weight high vs low DEGsPArEC FVC high vs low DEGsPArEC pack years high vs low DEGsPBFB DLCO high vs low DEGsPBFB current smoker vs never DEGsPBFB explant vs lobectomy DEGsPBFB former smoker vs never DEGsPBFB male vs female DEGsPBFB marker genesPBFB weight high vs low DEGsPC-prog COPD vs non-COPD DEGsPC-prog marker genesPCEC COPD vs non-COPD DEGsPCEC current smoker vs never DEGsPCEC explant vs lobectomy DEGsPCEC former smoker vs never DEGsPCEC male vs female DEGsPCEC marker genesPNEC DLCO high vs low DEGsPNEC FEV1/FVC high vs low DEGsPNEC FVC high vs low DEGsPNEC explant vs lobectomy DEGsPNEC former smoker vs never DEGsPNEC male vs female DEGsPNEC marker genesPNEC weight high vs low DEGsPVEC COPD vs non-COPD DEGsPVEC DLCO high vs low DEGsPVEC FEV1 high vs low DEGsPVEC FEV1/FVC high vs low DEGsPVEC cancer vs no cancer DEGsPVEC explant vs lobectomy DEGsPVEC former smoker vs never DEGsPVEC male vs female DEGsPVEC weight high vs low DEGsPericyte COPD vs non-COPD DEGsPericyte DLCO high vs low DEGsPericyte cancer vs no cancer DEGsPericyte explant vs lobectomy DEGsPericyte former smoker vs never DEGsPericyte male vs female DEGsPericyte marker genesPericyte pack years high vs low DEGsPericyte weight high vs low DEGsPlasma DLCO high vs low DEGsPlasma former smoker vs never DEGsPlasma male vs female DEGsPlasma marker genesPlasma pack years high vs low DEGsRASC COPD vs non-COPD DEGsRASC DLCO high vs low DEGsRASC FEV1 high vs low DEGsRASC FEV1/FVC high vs low DEGsRASC FVC high vs low DEGsRASC GOLD IV vs GOLD I-II DEGsRASC cancer vs no cancer DEGsRASC current smoker vs never DEGsRASC explant vs lobectomy DEGsRASC former smoker vs never DEGsRASC male vs female DEGsRASC marker genesRASC weight high vs low DEGsSAEC COPD vs non-COPD DEGsSAEC DLCO high vs low DEGsSAEC FEV1 high vs low DEGsSAEC FEV1/FVC high vs low DEGsSAEC GOLD IV vs GOLD I-II DEGsSAEC cancer vs no cancer DEGsSAEC explant vs lobectomy DEGsSAEC former smoker vs never DEGsSAEC male vs female DEGsSAEC marker genesSAEC weight high vs low DEGsSCMF COPD vs non-COPD DEGsSCMF DLCO high vs low DEGsSCMF FEV1/FVC high vs low DEGsSCMF cancer vs no cancer DEGsSCMF explant vs lobectomy DEGsSCMF former smoker vs never DEGsSCMF male vs female DEGsSCMF marker genesSCMF weight high vs low DEGsSPFB DLCO high vs low DEGsSPFB FEV1/FVC high vs low DEGsSPFB cancer vs no cancer DEGsSPFB male vs female DEGsSPFB marker genesSPFB pack years high vs low DEGsSPFB weight high vs low DEGsSVEC-act FEV1 high vs low DEGsSVEC-act FVC high vs low DEGsSVEC-act GOLD IV vs GOLD I-II DEGsSVEC-act cancer vs no cancer DEGsSVEC-act explant vs lobectomy DEGsSVEC-act male vs female DEGsSchwann COPD vs non-COPD DEGsSchwann GOLD IV vs GOLD I-II DEGsSchwann marker genesT-prolif FVC high vs low DEGsT-prolif weight high vs low DEGsTreg COPD vs non-COPD DEGsTreg DLCO high vs low DEGsTreg explant vs lobectomy DEGsTreg male vs female DEGsTreg marker genesTreg weight high vs low DEGsTuft COPD vs non-COPD DEGsTuft DLCO high vs low DEGsTuft FEV1 high vs low DEGsTuft FEV1/FVC high vs low DEGsTuft FVC high vs low DEGsTuft GOLD IV vs GOLD I-II DEGsTuft cancer vs no cancer DEGsTuft explant vs lobectomy DEGsTuft former smoker vs never DEGsTuft male vs female DEGsTuft marker genesTuft weight high vs low DEGscDC1 DLCO high vs low DEGscDC1 FEV1/FVC high vs low DEGscDC1 cancer vs no cancer DEGscDC1 current smoker vs never DEGscDC1 explant vs lobectomy DEGscDC1 male vs female DEGscDC1 marker genescDC1 weight high vs low DEGscVSMC DLCO high vs low DEGscVSMC FEV1/FVC high vs low DEGscVSMC cancer vs no cancer DEGscVSMC explant vs lobectomy DEGscVSMC former smoker vs never DEGscVSMC male vs female DEGscVSMC marker genescVSMC pack years high vs low DEGscVSMC weight high vs low DEGsiALF COPD vs non-COPD DEGsiALF DLCO high vs low DEGsiALF FEV1 high vs low DEGsiALF FEV1/FVC high vs low DEGsiALF FVC high vs low DEGsiALF GOLD IV vs GOLD I-II DEGsiALF cancer vs no cancer DEGsiALF explant vs lobectomy DEGsiALF male vs female DEGsiALF marker genesiALF weight high vs low DEGsiMON DLCO high vs low DEGsiMON FEV1 high vs low DEGsiMON FEV1/FVC high vs low DEGsiMON FVC high vs low DEGsiMON cancer vs no cancer DEGsiMON explant vs lobectomy DEGsiMON male vs female DEGsiMON marker genesiMON weight high vs low DEGsiNKT COPD vs non-COPD DEGsiNKT DLCO high vs low DEGsiNKT FEV1 high vs low DEGsiNKT FEV1/FVC high vs low DEGsiNKT FVC high vs low DEGsiNKT GOLD IV vs GOLD I-II DEGsiNKT cancer vs no cancer DEGsiNKT current smoker vs never DEGsiNKT explant vs lobectomy DEGsiNKT male vs female DEGsiNKT marker genesiNKT weight high vs low DEGsmaDC DLCO high vs low DEGsmaDC explant vs lobectomy DEGsmaDC male vs female DEGsmaDC marker genesmaDC weight high vs low DEGspDC COPD vs non-COPD DEGspDC DLCO high vs low DEGspDC male vs female DEGspDC marker genespMON DLCO high vs low DEGspMON FEV1 high vs low DEGspMON FEV1/FVC high vs low DEGspMON GOLD IV vs GOLD I-II DEGspMON cancer vs no cancer DEGspMON explant vs lobectomy DEGspMON male vs female DEGspMON marker genespMON weight high vs low DEGstMDM COPD vs non-COPD DEGstMDM DLCO high vs low DEGstMDM FEV1 high vs low DEGstMDM FEV1/FVC high vs low DEGstMDM FVC high vs low DEGstMDM GOLD IV vs GOLD I-II DEGstMDM cancer vs no cancer DEGstMDM current smoker vs never DEGstMDM explant vs lobectomy DEGstMDM former smoker vs never DEGstMDM male vs female DEGstMDM marker genestMDM weight high vs low DEGs
Gene symbols or identifiers, one per line.
COPD cell-state marker genes
Full-Size Heatmap

Derived locally from the COPD metacell pseudobulk table, log2 CP10k. Not fetched from www.lungmap.net.